Ammonium → 2-Fluoro-5-(4-methoxy-benzoyl)-benzenesulfonamide

HRID 1810151Notes

Reaction equation

HRID 1810151 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:17])[C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)=[CH:4][C:3]=1[S:18](Cl)(=[O:20])=[O:19].[NH4+:22]>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:17])[C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)=[CH:4][C:3]=1[S:18]([NH2:22])(=[O:20])=[O:19]

Participants

4

Reactant 2

HCID 223AmmoniumHCID 581074472-Fluoro-5-(4-methoxy-benzoyl)-benzenesulfonyl chloride

Product 1

HCID 442352782-Fluoro-5-(4-methoxy-benzoyl)-benzenesulfonamideYield 32%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-fluoro-5-(4-methoxy-benzoyl)-benzenesulfonyl chloride (0.45 g, 1.0 mmol) in methylene chloride is added aqueous ammonium solution (1 mL). The reaction mixture is stirred for 10 min at room temperature. The solvent is removed and the residue is redissolved in ethyl acetate and extracted with water. The organic layers are washed with a saturated sodium chloride solution, dried with magnesium sulfate, and concentrated in vacuo. The residue is recrystallized with methylene chloride-hexane to give 100 mg (32% yield) of the title compound as pale yellow solid. 1 NMR (CDCl3): δ 8.40 (m, 1H), 8.05 (m, 1H), 7.80 (d, J=8 Hz, 2H), 7.32 (t, 1H), 7.00 (d, J=8 Hz, 2H), 5.15 (s, 1H), 3.90 (s, 3H). Analytics calculated for C14H12FNO4S: C, 54.36; H, 3.91; N, 4.53. Found: C, 53.89; H, 3.50; N, 4.50.

Workup

  1. customThe solvent is removed
  2. dissolutionthe residue is redissolved in ethyl acetate
  3. extractionextracted with water
  4. washThe organic layers are washed with a saturated sodium chloride solution
  5. dry with materialdried with magnesium sulfate
  6. concentrationconcentrated in vacuo
  7. customThe residue is recrystallized with methylene chloride-hexane

Sources & evidence

ORD record
ord-db7e65a4332b40cda05954f840d8831a
Source dataset
uspto-grants-2013_01
Patent number
US08362063B2

Reaction notes

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