Sodium Carbonate → 7-Bromo-2,3,4,9-tetrahydro-pyrido[3,4-b]indol-1-one

Participants

Reaction Steps

A solution of 2,3-piperidinedione 3-(3-bromophenyl) hydrazone (2.5 g, 22.3 mmol) in formic acid (40 mL) is refluxed for 1 h then cooled to room temperature. The reaction mixture is neutralized with sodium carbonate to basic condition. The resulting precipitate is filtered and collected. Recrystallization with ethanol provides 1.0 g (56%) of the title compound as a yellow solid.

Provenance & Evidence