Potassium tert-butoxide → 1H-Indazole

HRID 1810222ノート

反応式

HRID 1810222 の反応式
C([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1)C1C=CC=CC=1.CC(C)([O-])C.[K+]>CS(C)=O>[NH:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]=[N:9]1

参加物

4

反応物 2

HCID 23665647Potassium tert-butoxideHCID 178420212HCID 178420212、化合物

生成物 1

HCID 92211H-Indazole

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

Benzyl-indazole is dissolved in dimethylsulfoxide and potassium tert-butoxide (1 M solution in tetrahydrofuran) is added at room temperature. Oxygen is then bubbled into the solution for 5 minutes. The reaction is allowed to stir at room temperature for 18 h. The reaction is quenched with aqueous saturated ammonium chloride then extracted three times with ethyl acetate. The combined organic extracts are dried over sodium sulfate, and concentrated. Purification by flash chromatography provides the deprotected indazole.

後処理

  1. customOxygen is then bubbled into the solution for 5 minutes
  2. customThe reaction is quenched with aqueous saturated ammonium chloride
  3. extractionthen extracted three times with ethyl acetate
  4. dry with materialThe combined organic extracts are dried over sodium sulfate
  5. concentrationconcentrated
  6. customPurification by flash chromatography

出典と根拠

ORDレコード
ord-62940f52d4534d01b8b76a743c6b1997
出典データセット
uspto-grants-2013_01
特許番号
US08362063B2

反応ノート

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