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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1810257Generated: November 3, 2026

2-Bromo-5-(trifluoromethyl)benzyl alcohol → (2'-Hydroxymethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

https://huagongshe.com/reaction/1810257

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-5-(trifluoromethyl)benzyl alcoholHCID 2756248—
ReactantMethyl 2-(4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetateHCID 57576289—
Product(2'-Hydroxymethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl esterHCID 66606415—

Reaction Steps

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: (2-bromo-5-trifluoromethyl-phenyl)-methanol and [4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08362044B2
Source datasetuspto-grants-2013_01
ORD IDord-e6193ce42f7c4e1b9b4df23310eb5310
Source noteuspto-grants-2013_01