Methyl chloroformate → {6-Methoxy-2'-[(methoxycarbonyl-phenethyl-amino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

HRID 1810272Notes

Reaction equation

HRID 1810272 reaction equation
[CH3:1][O:2][C:3](=[O:33])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=2[CH2:23][NH:24][CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1.Cl[C:35]([O:37][CH3:38])=[O:36]>>[CH3:1][O:2][C:3](=[O:33])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:21])([F:20])[F:22])=[CH:15][C:14]=2[CH2:23][N:24]([C:35]([O:37][CH3:38])=[O:36])[CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 6586Methyl chloroformateHCID 66607670[6-Methoxy-2'-(phenethylamino-methyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid methyl ester

Product 1

HCID 66608015{6-Methoxy-2'-[(methoxycarbonyl-phenethyl-amino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 23, Step 1, using the following starting materials: [6-methoxy-2′-(phenethylamino-methyl)-4-'-trifluoromethyl-biphenyl-3-yl]-acetic acid methyl ester and methyl chloroformate.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d5e895655ee54cfca9305c943dcb7777
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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