Hydrochloric Acid → (2'-{[Ethyl-(2-phenylsulfanyl-acetyl)-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

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Reaction Steps

(2′-{[Ethyl-(2-phenylsulfanyl-acetyl)-amino]-methyl}-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester (0.291 g, 0.53 mmol) in THF (3 mL) was treated with 1N aqueous LiOH (3 mL) at room temperature overnight. The mixture was acidified with 1N aqueous HCl and extracted three times with EtOAc. The combined organic layers were dried and concentrated, and the residue was purified by silica gel chromatography (30-70% EtOAc in hexanes) to give the title compound. M+H is 518.

Provenance & Evidence