Nitrogen → HCID 66634522, compound

Participants

Reaction Conditions

Reaction Steps

A solution of {2′-[(benzyloxycarbonyl-ethyl-amino)-methyl]-6-trifluoromethanesulfonyloxy-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester (0.11 g, 0.17 mmol), phenylboronic acid (0.023 g, 0.19mmol), and potassium carbonate (0.070 g, 0.51 mmol) in 2:1 DME:H2O (5 mL) was purged with N2 for 15 minutes. Tetrakis(triphenylphosphine)palladium(0) (0.020 g, 0.02 mmol) was added, and the reaction was purged with N2 for another 10 minutes, and then stirred at 90° C. overnight. The mixture was partitioned between EtOAc and H2O, and the aqueous layer was separated and extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered, and concentrated, and the residue was purified by preparative HPLC to give the title compound. M+H is 548.

Provenance & Evidence