Sulfuric Acid → HCID 86651107, compound

HRID 1810319Notes

Reaction equation

HRID 1810319 reaction equation
C(NC(=O)[N:10]([CH2:13][C:14]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:16][C:15]=1[C:24]1[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[C:26]([C@@H:34]([CH3:47])[C:35](N[C@H](C)CC2C=CC=CC=2)=[O:36])[CH:25]=1)[CH2:11][CH3:12])C1C=CC=CC=1.[OH:49]S(O)(=O)=O>O1CCOCC1>[CH2:11]([NH:10][CH2:13][C:14]1[CH:19]=[C:18]([C:20]([F:22])([F:23])[F:21])[CH:17]=[CH:16][C:15]=1[C:24]1[CH:29]=[C:28]([C:30]([F:32])([F:33])[F:31])[CH:27]=[C:26]([C@@H:34]([CH3:47])[C:35]([OH:36])=[O:49])[CH:25]=1)[CH3:12]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 86651108HCID 86651108, compound

Product 1

HCID 86651107HCID 86651107, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(R)-2-[2′-(3-Benzyl-1-ethyl-ureidomethyl)-5,4′-bis-trifluoromethyl-biphenyl-3-yl]-N—((R)-1-methyl-2-phenyl-ethyl)-propionamide (0.08 g, 0.12 mmol) was treated with 5N aqueous H2SO4 in 1,4-dioxane at 100° C. for 24 hours. The mixture was purified by preparative HPLC to give the title compound.

Workup

  1. customThe mixture was purified by preparative HPLC

Sources & evidence

ORD record
ord-fc55e88b1f094b30a3fd9772912d1e5e
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

Loading…