Methanol → HCID 86651109, compound

HRID 1810320Notes

Reaction equation

HRID 1810320 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:6]=1[C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([C@@H:25]([CH3:29])[C:26]([OH:28])=[O:27])[CH:16]=1)[CH3:2].[CH3:30]O>S(=O)(=O)(O)O>[CH3:30][O:27][C:26](=[O:28])[C@@H:25]([C:17]1[CH:16]=[C:15]([C:6]2[CH:7]=[CH:8][C:9]([C:11]([F:14])([F:13])[F:12])=[CH:10][C:5]=2[CH2:4][NH:3][CH2:1][CH3:2])[CH:20]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:18]=1)[CH3:29]

Participants

4

Reactant 2

HCID 887MethanolHCID 86651107HCID 86651107, compound

Product 1

HCID 86651109HCID 86651109, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

(R)-2-(2′-Ethylaminomethyl-5,4′-bis-trifluoromethyl-biphenyl-3-yl)-propionic acid (0.04 g, 0.10 mmol) in MeOH (2 mL) was treated with 2 drops of sulfuric acid at room temperature overnight. The mixture was concentrated, and the crude material was used directly in the next step.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-ea4f1373699b44969fc66752fdfc1440
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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