HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 2-(3-Bromo-4-methoxy-phenyl)-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | Ethyl 3-bromo-4-methoxyphenylacetate | HCID 57419861 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(3-Bromo-4-methoxy-phenyl)-propionic acid ethyl ester | HCID 57458804 | — |
Reaction Conditions
| Temperature | -78 °C |
|---|
Reaction Steps
To (3-bromo-4-methoxy-phenyl)-acetic acid ethyl ester (12.2 mmol) in THF was added iodomethane (0.75 mL, 12.2 mmol), and the mixture was cooled to −78° C. Sodium bis(trimethylsilyl)amide (1M in THF; 12.2 mL, 12.2 mmol) was added, and subsequent work-up gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362044B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-de620e9eef5a4828a60121c1764e861a |
| Source note | uspto-grants-2013_01 |