Sodium Iodide → HCID 66607956, compound

Participants

Reaction Steps

(2′-{[(2-Chloro-acetyl)-ethyl-amino]-methyl}-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester (0.55 mmol), pyrrolidine (0.05 mL, 0.61 mmol), potassium carbonate (0.152 g, 1.1 mmol), and sodium iodide (0.082 g, 0.55 mmol) were combined in MeCN (3 mL), and the reaction was stirred for 3 hours at room temperature. Analytical LCMS indicated that some starting material was still present, so additional potassium carbonate (0.053 g, 0.39 mmol) was added, and the reaction was stirred for 45 minutes. The mixture was diluted with EtOAc and H2O, and the aqueous layer was extracted twice with EtOAc. The combined organic layers were dried and concentrated to give the title compound.

Provenance & Evidence