Ethanol → HCID 66606831, compound

HRID 1810410Notes

Reaction equation

HRID 1810410 reaction equation
[CH2:1]([O:8][C:9]([N:11]([CH2:14][C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:16]=1[C:25]1[C:30]([O:31][CH3:32])=[CH:29][CH:28]=[C:27]([CH:33]([CH3:37])[C:34]([OH:36])=[O:35])[CH:26]=1)[CH2:12][CH3:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:38][CH2:39]O>S(=O)(=O)(O)O>[CH2:38]([O:35][C:34](=[O:36])[CH:33]([C:27]1[CH:26]=[C:25]([C:16]2[CH:17]=[CH:18][C:19]([C:21]([F:23])([F:24])[F:22])=[CH:20][C:15]=2[CH2:14][N:11]([C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[O:10])[CH2:12][CH3:13])[C:30]([O:31][CH3:32])=[CH:29][CH:28]=1)[CH3:37])[CH3:39]

Participants

4

Reactant 2

HCID 702EthanolHCID 54673215HCID 54673215, compound

Product 1

HCID 66606831HCID 66606831, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

2-{2′-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-propionic acid (0.058 g, 0.11 mmol) in EtOH (3 mL) was treated with sulfuric acid (2 drops) at 70° C. for 1.5 hours to give the title compound.

Sources & evidence

ORD record
ord-b49a84bed55d465884af03a5377360d8
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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