HCID 44158598, compound → HCID 66603992, compound

HRID 1810415Notes

Reaction equation

HRID 1810415 reaction equation
C(OC([N:11]([CH2:14][C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:16]=1[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH2:31][C:32]([OH:34])=[O:33])[CH:26]=1)[CH2:12][CH3:13])=O)C1C=CC=CC=1>CCO.[Pd]>[CH2:12]([NH:11][CH2:14][C:15]1[CH:20]=[C:19]([C:21]([F:22])([F:24])[F:23])[CH:18]=[CH:17][C:16]=1[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH2:31][C:32]([OH:34])=[O:33])[CH:26]=1)[CH3:13]

Participants

4

Reactant 1

HCID 44158598HCID 44158598, compound

Product 1

HCID 66603992HCID 66603992, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

{2′-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid (0.16 g, 0.34 mmol) in EtOH (7 mL) was treated with 10% palladium on carbon (0.072 g), and the reaction was stirred under a balloon of H2 for 3 hours to give the title compound.

Sources & evidence

ORD record
ord-8c709ae7ab31417ea9b60c7d0cfd0091
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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