(3-Bromo-4-cyclopropylmethoxy-phenyl)-acetic acid ethyl ester → {2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-6-cyclopropylmethoxy-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester

HRID 1810430Notes

Reaction equation

HRID 1810430 reaction equation
[CH2:1]([O:8][C:9](=[O:33])[N:10]([CH2:31][CH3:32])[CH2:11][C:12]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:13]=1B1OC(C)(C)C(C)(C)O1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:34]([O:36][C:37](=[O:51])[CH2:38][C:39]1[CH:44]=[CH:43][C:42]([O:45][CH2:46][CH:47]2[CH2:49][CH2:48]2)=[C:41](Br)[CH:40]=1)[CH3:35]>>[CH2:34]([O:36][C:37](=[O:51])[CH2:38][C:39]1[CH:40]=[C:41]([C:13]2[CH:14]=[CH:15][C:16]([C:18]([F:19])([F:20])[F:21])=[CH:17][C:12]=2[CH2:11][N:10]([C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:33])[CH2:31][CH3:32])[C:42]([O:45][CH2:46][CH:47]2[CH2:49][CH2:48]2)=[CH:43][CH:44]=1)[CH3:35]

Participants

3

Reactant 2

HCID 58149222(3-Bromo-4-cyclopropylmethoxy-phenyl)-acetic acid ethyl esterHCID 66603618(Ethyl)[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethylbenzyl]carbamic acid benzyl ester

Product 1

HCID 66607617{2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-6-cyclopropylmethoxy-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: ethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid benzyl ester and (3-bromo-4-cyclopropylmethoxy-phenyl)-acetic acid ethyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e926d10ed5db41a781e66173c6a3bb50
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

Loading…