Ethylamine → (5-Chloro-2'-ethylaminomethyl-4'-fluoro-biphenyl-3-yl)-acetic acid ethyl ester

HRID 1810444Notes

Reaction equation

HRID 1810444 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:7]=[C:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[CH:20]=O)[CH:9]=[C:10]([Cl:12])[CH:11]=1)[CH3:2].[CH2:23]([NH2:25])[CH3:24]>>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:7]=[C:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[CH2:20][NH:25][CH2:23][CH3:24])[CH:9]=[C:10]([Cl:12])[CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 58149191(5-Chloro-4'-fluoro-2'-formyl-biphenyl-3-yl)-acetic acid ethyl ester

Product 1

HCID 58148881(5-Chloro-2'-ethylaminomethyl-4'-fluoro-biphenyl-3-yl)-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 5, using the following starting materials: (5-chloro-4′-fluoro-2′-formyl-biphenyl-3-yl)-acetic acid ethyl ester and ethylamine (2M in THF).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9c49c12b71c44f8f87c4341f9f751e8d
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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