2-Bromo-5-(trifluoromethyl)benzaldehyde → HCID 86651119, compound

HRID 1810466Notes

Reaction equation

HRID 1810466 reaction equation
C([O:3][C:4](=[O:25])[C:5]([F:24])([F:23])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8](B2OC(C)(C)C(C)(C)O2)[CH:7]=1)C.Br[C:27]1[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][C:28]=1[CH:29]=[O:30]>>[F:24][C:5]([F:23])([C:6]1[CH:7]=[C:8]([C:27]2[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][C:28]=2[CH:29]=[O:30])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[C:4]([OH:3])=[O:25]

Participants

3

Reactant 2

HCID 70180472-Bromo-5-(trifluoromethyl)benzaldehydeHCID 58149078HCID 58149078, compound

Product 1

HCID 86651119HCID 86651119, compound

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: difluoro-[4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester and 2-bromo-5-(trifluoromethyl)benzaldehyde; the ester was hydrolyzed under the reaction conditions.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7b701a2376614587a956997421702634
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

Loading…