5-Methoxy-2-formylphenylboronic acid → (5-Chloro-2'-formyl-5'-methoxy-biphenyl-3-yl)-acetic acid methyl ester

HRID 1810509Notes

Reaction equation

HRID 1810509 reaction equation
[CH3:1][O:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[C:7](Br)[CH:6]=1.[CH:14]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:17]=1B(O)O)=[O:15]>>[CH3:1][O:2][C:3](=[O:13])[CH2:4][C:5]1[CH:6]=[C:7]([C:21]2[CH:20]=[C:19]([O:22][CH3:23])[CH:18]=[CH:17][C:16]=2[CH:14]=[O:15])[CH:8]=[C:9]([Cl:11])[CH:10]=1

Participants

3

Reactant 2

HCID 27343665-Methoxy-2-formylphenylboronic acidHCID 58149292Methyl 2-(3-bromo-5-chlorophenyl)acetate

Product 1

HCID 58149196(5-Chloro-2'-formyl-5'-methoxy-biphenyl-3-yl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: (3-bromo-5-chloro-phenyl)-acetic acid methyl ester and 2-formyl-5-methoxyphenylboronic acid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2f3478bbd0a54bb09eab7392eae0b6b7
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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