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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1810563Generated: October 31, 2026

Ethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid 4-chloro-benzyl ester → (2'-{[(4-Chloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-5,4'-bis-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

https://huagongshe.com/reaction/1810563

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid 4-chloro-benzyl esterHCID 66607359—
ReactantHCID 86651106HCID 86651106—
Product(2'-{[(4-Chloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-5,4'-bis-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl esterHCID 86651133—

Reaction Steps

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: ethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid 4-chloro-benzyl ester and (3-trifluoromethanesulfonyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08362044B2
Source datasetuspto-grants-2013_01
ORD IDord-998f95208c1e40b19fd32c794c541f7a
Source noteuspto-grants-2013_01