反应详情

1-(2-Hydroxymethyl-phenyl)-ethanol (prepared according to the procedure described in P. Canonne et al., Tetrahedron 44 (1988), 2903-2912) (0.376 g, 2.47 mmol) was dissolved in DCM. Thionyl chloride (2.94 g, 24 mmol) was added and allowed to react for 1 h. The mixture was partitioned between EA and an excess of an aqueous sodium hydrogencarbonate solution. The combined organic extracts were dried over sodium sulfate, filtered and evaporated to dryness in vacuo. The residue was purified by silica gel chromatography with HEP to yield 0.228 g of the title compound.

1. customto react for 1 h
2. customThe mixture was partitioned between EA
3. dry with materialThe combined organic extracts were dried over sodium sulfate
4. filtrationfiltered
5. customevaporated to dryness in vacuo
6. customThe residue was purified by silica gel chromatography with HEP