反应详情

The compound of example 241 (32 mg, 0.074 mmol) was dissolved in ethanol (10 ml), palladium (10%) on charcoal (10 mg) was added, and the mixture was hydrogenated at room temperature for 1 h at a hydrogen pressure of 5 bar. After completion of the reaction, the mixture was filtered over silica gel and evaporated to dryness. The residue was triturated with diethyl ether, filtered and dried in vacuo to yield 25 mg of the title compound.

1. customAfter completion of the reaction
2. filtrationthe mixture was filtered over silica gel
3. customevaporated to dryness
4. customThe residue was triturated with diethyl ether
5. filtrationfiltered
6. customdried in vacuo