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Acetic Anhydride → Acetic acid 2-[3-(2-hydroxy-ethyl)-phenyl]-ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 2-[3-(2-Hydroxyethyl)phenyl]ethanol | HCID 10080741 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Acetic acid 2-[3-(2-hydroxy-ethyl)-phenyl]-ethyl ester | HCID 67076325 | 41.6% |
反応手順
2-[3-(2-Hydroxy-ethyl)-phenyl]-ethanol (2.49 g, 15.0 mmol) was dissolved in ACN (5 ml) and acetic anhydride (3.06 g, 30 mmol) added. The mixture was stirred under reflux for 1 h and then evaporated to dryness. Silica gel chromatography (HEP/EA gradient) of the residue yielded 1.30 g of the title compound (mono-acetylated product).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08362073B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-9b4f93d053c0435aba758a216e7dcccf |
| 出典メモ | uspto-grants-2013_01 |