Sodium hydride → 2-{4-[2-(2,4-dimethyl-imidazol-1-yl)-acetyl]-piperazin-1-yl}-N-phenyl-benzamide

참여 물질

반응 조건

반응 단계

To 2,5-dimethyl imidazole (0.060 g, 0.630 mmol) in 1 mL of DMSO in a reaction tube is added 60% NaH (0.030 g, 0.730 mmol). The mixture bubbles as deprotonation occurs. The mixture is stirred for 0.5 h and then 0.5 mL of a DMSO solution containing 2-[4-(2-chloro-acetyl)-piperazin-1-yl]-N-phenyl-benzamide (0.075 g, 0.210 mmol) is added. The flask is sealed and heated at 80° C. for 60 h. The product is purified via Prep HPLC (20-100% CH3CN/H2O) to give 74.7 mg of 2-{4-[2-(2,4-dimethyl-imidazol-1-yl)-acetyl]-piperazin-1-yl}-N-phenyl-benzamide in 85% yield. MS: MH+=418.9

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