反应详情

To (3,5-dimethyl-pyrazol-1-yl)-acetic acid (0.140 g, 0.908 mmol) in DMF is added carbonyl diimidazole (0.140 g, 0.863 mmol) in one portion. The mixture is stirred for 1 h. To this is added 1-(2-nitro-phenyl)-piperazine (0.197 g, 0.950 mmol). The mixture is stirred for 14 h and then diluted with 100 mL EtOAc. The reaction is quenched with 20 mL of saturated NH4Cl, washed with 2×20 mL of H2O and 1×20 mL of brine. The organic phase is dried (MgSO4), filtered and concentrated to give 2-(3,5-dimethyl-pyrazol-1-yl)-1-[4-(2-nitro-phenyl)-piperazin-1-yl]-ethanone in 64% yield.

1. stirringThe mixture is stirred for 14 h
2. customThe reaction is quenched with 20 mL of saturated NH4Cl
3. washwashed with 2×20 mL of H2O and 1×20 mL of brine
4. dry with materialThe organic phase is dried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated