Hydrochloric Acid → HCID 57516323, compound

Participants

Reaction Steps

To a solution of 4-[5-chloro-3-(3-trifluoromethyl-benzoylamino)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester (1.40 g, 2.89 mmol) in methylene chloride (100 mL) is added hydrogen chloride (3.00 mL, 12 mmol) as a 4.0 M solution in 1,4-dioxane. The mixture is stirred at room temperature for 2 days during which time a solid precipitates from solution. The off-white solid is collected by filtration, washed with methylene chloride and dried on the filter pad to afford 1.20 g of N-(5-chloro-2-piperazin-1-yl-pyridin-3-yl)-3-trifluoromethyl-benzamide in 100% yield.

Provenance & Evidence