Pyridine → HCID 66599594, compound

Participants

Reaction Steps

To solution of (4-chloro-3,5-dimethyl-pyrazol-1-yl)-acetic acid (0.051 g, 0.160 mmol) in N,N-dimethylformamide (2 mL) is added pyridine (0.006 mL, 0.07 mmol) followed by 0.123 g (0.324 mmol) of tetramethyluroniumhydroxybenzotriazolehexaflourophosphate. The mixture stirred for 1 h. To this is added of N-(5-chloro-2-piperazin-1-yl-pyridin-3-yl)-3-trifluoromethyl-benzamide (0.031 g, 0.162 mmol). The mixture is allowed to stir overnight. The mixture is concentrated under reduced pressure and is purified by reverse phase HPLC to provide 0.010 g of N-(5-chloro-2-{4-[2-(4-chloro-3,5-dimethyl-2H-pyrrol-2-yl)-acetyl]-piperazin-1-yl}-pyridin-3-yl)-3-trifluoromethyl-benzamide in 21% yield. MS; MH+=558.8

Provenance & Evidence