Hydrochloric Acid → HCID 66609817, compound

Participants

Reaction Steps

To a solution of 4-[4-chloro-2-(3-chloro-benzoylamino)-phenyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester (0.100 g, 0.215 mmol) in acetonitrile (5 mL) is added 2.0 mL of hydrogen chloride as a 4.0 M solution in 1,4-dioxane. The mixture is stirred at room temperature for 48 h during which time a solid precipitates from solution. The off-white solid is collected by filtration, washed with methylene chloride and dried on the filter pad to provide 0.070 g of 3-chloro-N-(5-chloro-2-[1,4]diazepan-1-yl-phenyl)-benzamide.

Provenance & Evidence