Pyridine → HCID 59548739, compound

Participants

Reaction Steps

To solution of (3,5-dimethyl-pyrazol-1-yl)-acetic acid (0.010 g, 0.068 mmol) in N,N-dimethylformamide (2 mL) is added 0.006 mL (0.071 mmol) of pyridine followed by) tetramethyluroniumhydroxybenzotriazolehexaflourophosphate (0.123 g, 0.324 mmol). The mixture stirred for 1 hour. To this is added 3-chloro-N-(5-chloro-2-[1,4]diazepan-1-yl-phenyl)-benzamide (0.025 g, 0.068 mmol). The mixture is allowed to stir overnight. The mixture is concentrated under reduced pressure and is purified by reverse phase HPLC to provide 0.010 g of 3-chloro-N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-[1,4]diazepan-1-yl}-pyridin-3-yl)-benzamide in 29% yield. MS MH+=501.8

Provenance & Evidence