HCID 59548815, compound → HCID 59548769, compound

Participants

Reaction Steps

To a solution of 3-chloro-N-(5-chloro-2-{1-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-phenyl)-benzamide (0.100 g, 0.207 mmol) in ethanol (5 mL) is added Pd on 5% activated carbon (10 mg) in a round bottom flask and the mixture is purged three times and back filled with H2 using a H2 filled balloon. The reaction is allowed to stir at room temperature for 20 h. The reaction is filtered through a pad of diatomaceous earth and washed with MeOH. The filtrate is concentrated and purified via preparative HPLC. Removal of the solvent gives 0.010 g of N-(5-chloro-2-{1-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-phenyl)-benzamide in 10% yield. MS MH+=450.2 and 0.030 g of N-(2-{1-[2-(3,5-Dimethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-phenyl)-benzamide in 35% yield. MS MH+=417.3.

Provenance & Evidence