HCID 59548763, compound → HCID 46945413, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-chloro-1-(2-{4-[2-(4-methanesulfonyl-phenylcarbamoyl)-phenyl]-piperazin-1-yl}-2-oxo-ethyl)-1H-indole-2-carboxylic acid ethyl ester (0.14 g, 0.22 mmol) of in a 1:1:1 mixture of water/MeOH/1,4-dioxane (9 mL) is heated at 50° C. for 1 hour during which time all of the solids went into solution. The mixture is cooled to room temperature and concentrated under reduced pressure to remove volatile organics. The pH of the mixture is adjusted to slightly acidic (approx pH 5) by the addition of a 2N solution of hydrochloric acid which caused a solid to precipitate from solution. The formed solid is collected by filtration, washed with water and dried on the filter pad to provide 0.025 g of 5-chloro-1-(2-{4-[2-(4-methanesulfonyl-phenylcarbamoyl)-phenyl]-piperazin-1-yl}-2-oxo-ethyl)-1H-indole-2-carboxylic acid as an off white powder.

Provenance & Evidence