1,2-Dichloroethane → HCID 59548746, compound

Participants

Reaction Conditions

Reaction Steps

Dissolved 4-(2-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.30 g, 0.98 mmol), EDC (0.23 g, 1.20 mmol) and HOBT (0.18 g, 1.20 mmol) into 1 mL of DMF. The mixture stirred for 1 h. To this is added 5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine (0.16 g, 0.98 mmol) and N,N-diisopropylethylamine (0.37 mL, 2.00 mmol). The mixture is placed under a stream of Ar and heated at 50° C. for 16 h. The mixture is then diluted with 50 mL CH2Cl2, quenched with 20 mL of saturated NH4Cl; washed with 2×20 mL of H2O, and washed with 1×20 mL of brine. The resultant organic phase was dried with MgSO4, filtered and concentrated to provide 0.38 g, 85% yield of 4-[2-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester.

Provenance & Evidence