325465-53-0 → HCID 178506734, compound

HRID 1811360Notes

Reaction equation

Br[C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[CH2:11][CH3:12].C([Li:17])CCC>>[Li:17][C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[CH2:11][CH3:12]

Participants

Reactant 2

HCID 3790709325465-53-0

HCID 178418339Butyllithium

Product 1

HCID 178506734HCID 178506734, compound

Procedure

comprising contacting 3-bromo-2-ethylbenzofuran with n-butyllithium at a temperature less than −75° C. to form 3-lithio-2-ethylbenzofuran, contacting the 3-lithio-2-ethylbenzofuran at a temperature less than −75° C. with an isopropyl boronate cyclic ester corresponding to the formula:

Workup

customat a temperature less than −75° C.

Sources & evidence

ORD record: ord-cb5c7ed08f6845ca8044420d8e9ebdab
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08362265B2

Reaction notes

Loading…