Potassium Carbonate → HCID 67042683, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1-Chloro-4-iodobenzene	HCID 12510	—
Reactant	HCID 19820140	HCID 19820140	—
Reactant	HCID 178419375	HCID 178419375	—
Catalyst	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
Solvent	Toluene	HCID 1140	—
Solvent	Ethyl acetate hexane	HCID 21226206	—
Product	HCID 67042683	HCID 67042683	53%

Reaction Conditions

Temperature	100 °C

Reaction Steps

A suspension consisting of 3-(2-bromobenzyloxy)-1H-pyrazole (0.20 g, 0.91 mmol), 4-chloroiodobenzene (0.17 g, 0.73 mmol), CuI (9 mg, 0.05 mmol), K2CO3 (0.05 mg, 0.38 mmol) and N,N′-dimethylcyclohexanediamine (72 μL, 0.46 mmol) in 2 mL of toluene was heated to 100° C. for 20 h. The mixture was then cooled to room temperature and directly subjected to column chromatography (SiO2, hexane/ethyl acetate=100:0 to 80:20). The product was obtained as a colorless solid (140 mg, 0.14 mmol, 53% yield).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08362271B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-752c15c09911438ebcba1ec290d89511
Source note	uspto-grants-2013_01