Cesium carbonate → HCID 68996578, compound

Participants

Reaction Conditions

Reaction Steps

The above styrene is reduced under conditions outlined in. The styrene is dissolved in i-PrOH and toluene and degassed for 10 minutes. Then Cs2CO3 (22 mg, 0.07 mmol), [Ir(cod)Cl]2 (44 mg, 0.07 mmol), and dppp (27 mg, 0.07 mmol) are added and the reaction is heated to 80° C. over night. The cooled solution is concentrated in vacuo and the residue purified by flash chromatography eluting with 10, then 20, then 30% EtOAc/hexanes to give the title 5-methyl-2-(2′-fluoro-4′-ethyl-3′-trifluoromethylanilino)phenylacetic acid N,N-dimethyl amide.

Provenance & Evidence