3-Fluoro-5-iodoaniline → 6-Chloro-N-(3-fluoro-5-iodo-phenyl)-nicotinamide

HRID 181160Notes

Reaction equation

HRID 181160 reaction equation
[Cl:10][c:11]1[n:12][cH:13][c:14]([C:15](=[O:16])[Cl:17])[cH:18][cH:19]1.[Cl:20][c:21]1[cH:22][cH:23][c:24]([C:25]([NH:26][c:27]2[cH:28][cH:29][c:30]([I:31])[c:32]([CH3:33])[cH:34]2)=[O:35])[cH:36][n:37]1.[F:1][c:2]1[cH:3][c:4]([NH2:5])[cH:6][c:7]([I:9])[cH:8]1>>[F:1][c:2]1[cH:3][c:4]([NH:5][C:15]([c:14]2[cH:13][n:12][c:11]([Cl:10])[cH:19][cH:18]2)=[O:16])[cH:6][c:7]([I:9])[cH:8]1

Participants

4

Reactant 3

HCID 27589863-Fluoro-5-iodoanilineHCID 27821656-Chloronicotinoyl ChlorideHCID 593181386-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide

Product 1

HCID 593179696-Chloro-N-(3-fluoro-5-iodo-phenyl)-nicotinamide

Sources & evidence

ORD record
ord-c18b461137ae42abaea06e6ee4bdadb2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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