Water → HCID 59224649, compound

Participants

Reaction Conditions

Reaction Steps

Commercially available 2-amino-4,6-dichloropyrimidine (460 mg, 2.8 mmol), palladium dichloride-diphenylphosphinoferrocene dichloromethane complex (98 mg, 0.12 mmol), sodium bicarbonate (471 mg, 5.61 mmol), 1,4-dioxane (4.5 ml), and water (2.5 ml) were placed in a reaction vessel. The resulting mixture was stirred at 80° C. for 10 minutes. 2,4-Dimethyl-5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzoic acid tert-butyl ester (620 mg, 1.8 mmol) obtained in Step 3 above that was dissolved in 1,4-dioxane (4.5 ml) was added dropwise to the mixture. The resulting mixture was stirred at 80° C. for 19 hours. The reaction solution was diluted with ethyl acetate (150 ml), and washed with water (80 ml) three times and then with a saturated aqueous sodium chloride solution (80 ml). The washed ethyl acetate solution was dried over anhydrous sodium sulfate (30 g). After filtration, the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (developing solvent: n-hexane:ethyl acetate=10:1 to 5:1) to yield 5-(2-amino-6-chloropyrimidin-4-yl)-2,4-dimethylbenzoic acid tert-butyl ester (Compound 1-1) (422 mg) as a white solid material.

Provenance & Evidence