Water → HCID 59224665, compound

Participants

Reaction Steps

(S)-4-Amino-18,20-dimethyl-10,16-dioxo-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.12,6]docosa-1(20),2(22),3,5,17(21),18-hexaene-14-carboxylic acid methyl ester (1.1 g) obtained in Example 2-12 was dissolved in methanol (24.8 ml), and then a 1N aqueous sodium hydroxide solution (2.7 ml) was added thereto at room temperature. The resulting mixture was stirred at room temperature for six hours, and then water (80 ml) was added thereto. The precipitate was collected by filtration, washed with water, and then dried under reduced pressure to yield (S)-4-amino-18,20-dimethyl-10,16-dioxo-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.12,6]docosa-1(20),2(22),3,5,17(21),18-hexaene-14-carboxylic acid (Compound 64) (0.92 g) as a white solid material.

Provenance & Evidence