Trifluoroacetic acid → HCID 59224712, compound

Participants

Reaction Steps

5-[2-Amino-6-(2-tert-butoxycarbonylaminoethylsulfanyl)pyrimidin-4-yl]-2,4-dimethylbenzoic acid methyl ester (531 mg, 1.23 mmol) obtained in Step 1 above was dissolved in dichloromethane (3.0 ml). Trifluoroacetic acid (1.5 ml) was added to the solution, and stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure. The resulting residue was diluted with ethyl acetate, and then a saturated aqueous sodium bicarbonate solution was added thereto. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layers were combined together, and sequentially washed with water and a saturated aqueous sodium chloride solution. The ethyl acetate solution was dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to yield the crude product of 5-[2-amino-6-(2-aminoethylsulfanyl)pyrimidin-4-yl]-2,4-dimethylbenzoic acid methyl ester (443 mg) as a white solid material.

Provenance & Evidence