HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1811766Generated: November 2, 2026
Ammonium Hydroxide → 6-Chloro-2-methylpyrimidine-4,5-diamine
https://huagongshe.com/reaction/1811766
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 4,6-Dichloro-2-methylpyrimidin-5-amine | HCID 736674 | — |
| Product | 6-Chloro-2-methylpyrimidine-4,5-diamine | HCID 594145 | — |
Reaction Steps
2-methyl-4,6-dichloro-5-aminopyrimidine (Aldrich, 1.05 g) and ammonium hydroxide (3.0 mL, J.T. Baker, Phillipsburg, N.J., 28.0%-30.0%) were placed in a microwave vial. The vial was sealed and heated in a CEM microwave reactor (CEM Corporation, Matthews, N.C.) at 120° C. and 40 Watts for 25 minutes. The reaction was cooled to room temperature. This procedure was repeated a total of nine times using the following amounts of 2-methyl-4,6-dichloro-5-aminopyrimidine under the same reaction conditions:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08362241B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-ac8ab8bdcf7043feb620efaf645dadf2 |
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| Source note | uspto-grants-2013_01 |
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