5-Amino-2,2-difluoro-1,3-benzodioxole → 4-(2-(2,2-Difluorobenzo[D][1,3]dioxol-5-ylamino)pyridin-3-YL)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Reaction Steps

The title compound was prepared in an analogous manner to that described in Example 164 using 2,2-difluorobenzo[d][1,3]dioxol-5-amine (0.055 g, 0.320 mmol) (Apollo Scientific Limited) and 4-(2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine (0.095 g, 0.213 mmol), and isolated as a brown oil (100%). 1H NMR (400 MHz, d6-DMSO) δ 11.98 (br. s., 1H); 8.79 (d, J=7.6 Hz, 1H); 8.35 (br. s., 1H); 7.92 (br. s., 1H); 7.20-7.29 (m, 5H); 7.16 (d, J=8.4 Hz, 1H); 6.83-6.97 (m, 5H); 4.81 (d, J=7.4 Hz, 4H); 3.72 (d, J=12.7 Hz, 6H); 2.57 (br. s., 3H). m/z (ESI, +ve ion) 599.0 (M+H)+.

Provenance & Evidence