3-Methyl-3H-imidazo[4,5-b]pyridin-6-amine → HCID 59548248, compound

Participants

Reaction Steps

The title compound was prepared in an analogous manner to that described in Example 197 (starting from Step 2) using 4-(2-fluoro-5-((4-(methylsulfonyl)piperazin-1-yl)methyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine (388 mg, 0.624 mmol) and 3-methyl-3H-imidazo[4,5-b]pyridin-6-amine (Adesis) as starting materials. 1H NMR (400 MHz, d6-DMSO) δ 12.00 (s, 1H); 8.73 (d, J=2.3 Hz, 1H); 8.67 (m, 2H); 8.36 (s, 1H); 8.26 (d, J=2.5 Hz, 1H); 7.93 (br, 1H); 7.74 (br, 1H); 3.84 (s, 3H); 3.50 (s, 2H); 3.11 (m, 4H); 2.87 (s, 3H); 2.48-2.49 (m, 4H); 2.49 (m, 3H). m/z (ESI, +ve ion) 510 (M+H)+.

Provenance & Evidence