Bromomethyl 4-methoxyphenyl ketone → HCID 178444638, Verbindung
Reaktionsgleichung
C#CCCCCC=O.COc1ccc(C(=O)CBr)cc1>C[C@@H]1[NH2+][C@@H](C(C)(C)C)N(C)C1=O.[O-]S(=O)(=O)C(F)(F)F.COc1ccc(-c2cc(-c3ccc(OC)cc3)[o+]c(-c3ccc(OC)cc3)c2)cc1.[B-](F)(F)(F)F.CN(C)C=O.Cc1cccc(C)n1>C#CCCC[C@@H](C=O)CC(=O)c1ccc(OC)cc1.C#CCCC[C@H](C=O)CC(=O)c1ccc(OC)cc1Komponenten
8
Edukt 3
Produkt 2
Reagenzien, Katalysatoren, Lösungsmittel 3
Reaktionsbedingungen
- Temperatur
- 22 °C
Aufarbeitung
- aliquot4 uL mixture of each reacted solution was collected and diluted with 36 uL ACN
- addition4 uL mixture of each reacted solution was collected and diluted with 36 uL ACN
- additionchiral resolving regent (150 mM in DCM, 40 uL)
- additionCuI with DIPEA (400 mM in ACN) 40 uL
- additioninternal standard 1-phenylprop-2-yn-1-ol (4) (25 mM in ACN) 40 uL
- stirringKeine Vorschrift aufgezeichnet
- aliquotAfter the reaction, 10 uL of supernatant for each reaction was transferred to another 96-well plate
- additionAfter the reaction, 10 uL of supernatant for each reaction was transferred to another 96-well plate and diluted with 190 uL ACN before the IM-MS analysis
Quellen und Nachweise
- ORD-Eintrag
- ord-07d8a8f30fcd4c289406779c01700ccc
- Quelldatensatz
- Dataset from `Ultra-high-throughput mapping of the chemical space of asymmetric catalysis enables accelerated reaction discovery`
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