HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyaniline → HCID 22501705, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyaniline | HCID 10824 | — |
| Reactant | tert-Butyl [(3S)-2-oxooxetan-3-yl]carbamate | HCID 2763194 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22501705 | HCID 22501705 | — |
Reaction Steps
To a solution of m-anisidine (171 mg, 1.38 mmol) in THF (30 ml), N-(tert-butoxycarbonyl)-L-serine β-lactone (200 mg, 1.06 mmol) was added, and the mixture was refluxed overnight under argon. The reaction mixture was concentrated on a rotary evaporator. The residue was subjected to flash column chromatography, eluting with EtOAc/hexanes of various compositions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06875757B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-466eff6806e449e785e962e6544c27f2 |
| Source note | uspto-grants-2005_04 |