HCID 10286610, compound → HCID 22504458, compound

HRID 1813897Notes

Reaction equation

HRID 1813897 reaction equation
[C:1]1([S:7]([C:10]2[C:15](=[NH:16])[N:14]3[CH:17]=[CH:18][CH:19]=[CH:20][C:13]3=[N:12][C:11]=2SC)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:23][OH:24].O>CO>[C:1]1([S:7]([C:10]2[C:15](=[NH:16])[N:14]3[CH:17]=[CH:18][CH:19]=[CH:20][C:13]3=[N:12][C:11]=2[O:24][CH3:23])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 10286610HCID 10286610, compoundHCID 22242641Methanol--water (1/1)

Product 1

HCID 22504458HCID 22504458, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
90 °C

Procedure

3-Benzenesulfonyl-2-methylsulfanyl-pyrido[1,2-a]pyrimidin-4-ylideneamine (50 mg, 0.15 mmol) was dissolved in methanol (2 ml) and heated at 90° C. for 4 days. When the conversion reached about 50% the product was isolated from the starting material by preparative HPLC (XTerra™ MS C18 5.0 mM, MeOH/H2O as the eluent) to yield 21 mg of bright yellow product.

Sources & evidence

ORD record
ord-8b4ca63dafb64d088fcd86fcbb4c12f8
Source dataset
uspto-grants-2005_04
Patent number
US06875771B2

Reaction notes

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