Tolylboronic acid → HCID 69421305, compound

Participants

Reaction Steps

Following the method described in Example 8, 4-(5-chloro-2-methoxy-phenyl)-pyridine-2,6-diamine trifluoroacetic acid salt and p-tolylboronic acid provided the title compound (11% yield). 1H NMR (acetone-d6) δ2.26 (s, 3H, CH3), 3.83 (s, 3H, CH3) 5.24 (bs, 2H, NH2), 6.10 (d, 1H, J=1.1 Hz, Ar), 6.26 (t, 1H, J=1.1 Hz, Ar), 7.06 (d, 2H, J=8.5 Hz, Ar), 7.08 (d, 1H, J=8.8 Hz, Ar), 7.29 (d, 1H, J=2.7 Hz, Ar), 7.35 (dd, 1H, J=9.0 Hz, J=3.3 Hz, Ar), 7.53-7.56 (m, 2H, Ar), 7.70 (s, 1H, NH).

Provenance & Evidence