HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1813991Generated: November 3, 2026
Hydrochloric Acid → 4-(Methanesulfonyl)piperidine
https://huagongshe.com/reaction/1813991
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate | HCID 22504298 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(Methanesulfonyl)piperidine | HCID 22275038 | — |
Reaction Steps
tert-Butyl 4-(methylsulfonyl)piperidine-1-carboxylate 5-4 (12.270 g, 46.59 mmol) was dissolved in 80 mL EtOAc and the solution was cooled to 0° C. 4.0M HCl in dioxane (58.240 mL, 232.95 mmol) was added and the solution was allowed to warm to room temperature. After 5 hours the reaction was concentrated in vacuo to afford 4-(methylsulfonyl)piperidine 5-5 as a white solid. HCl salt:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06875767B2 |
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| Source dataset | uspto-grants-2005_04 |
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| ORD ID | ord-ff7859128c1a43ec92a74ff96e0ab00c |
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| Source note | uspto-grants-2005_04 |
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