Hydrochloric Acid → HCID 55299026, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl-(3R)-3-{[(methylamino)carbonyl]amino}pyrrolidine-1-carboxylate 6-3 (2.174 g, 8.93 mmol) was dissolved in 3 mL CH2Cl2 and the solution was cooled to 0° C. 4.0M HCl in dioxane (33.50 mL, 134.0 mmol) was added and the solution was allowed to warm to room temperature. After 4.5 hours the reaction was concentrated in vacuo to afford N-methyl-N′-[(3R)-pyrrolidin-3-yl]urea 6-4 as an off-white solid. HCl salt: 1H NMR (DMSO-d6) δ 9.13 (bs, 2H), 4.15 (m, 1H), 3.10-3.3.29 (m, 3H), 2.96-2.87 (m, 1H), 2.54 (s, 3H), 2.13-2.01 (m, 1H), 1.75 (m, 1H).

Provenance & Evidence