HCID 20770807, compound → 2-[3-Methoxy-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenyl]-2-methyl-propionic acid methyl ester

HRID 1814165Notes

Reaction equation

HRID 1814165 reaction equation
[CH3:1][O:2][C:3](=[O:33])[C:4]([C:7]1[CH:12]=[CH:11][C:10]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23]N=3)=[CH:17][CH:16]=2)=[C:9]([O:31][CH3:32])[CH:8]=1)([CH3:6])[CH3:5].[CH3:34]OC(=O)C(C1C=CC(S)=C(OC)C=1)(C)C>>[CH3:1][O:2][C:3](=[O:33])[C:4]([C:7]1[CH:12]=[CH:11][C:10]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:34]=[CH:23][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:25][CH:26]=3)=[CH:17][CH:16]=2)=[C:9]([O:31][CH3:32])[CH:8]=1)([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 20770807HCID 20770807, compoundHCID 207708082-(4-Mercapto-3-methoxy-phenyl)-2-methyl propionic acid methyl ester

Product 1

HCID 207708062-[3-Methoxy-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenyl]-2-methyl-propionic acid methyl esterYield 34%

Procedure

Compound 47A was prepared analogously to compound 21D using the product prepared from compound 21C. Yield was 34% after flash column purification. MS m/z 475 (M+1).

Workup

  1. customYield was 34% after flash column purification

Sources & evidence

ORD record
ord-b387db04f4744390884ceef77ff681df
Source dataset
uspto-grants-2005_04
Patent number
US06875780B2

Reaction notes

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