HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6-Mercapto-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid methyl ester → (6-Chlorosulfonyl-2-oxo-3,4-dihydro-2H-quinolin-1-yl) acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6-Mercapto-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid methyl ester | HCID 20770803 | — |
| Reactant | 2-(4-Chlorosulfonyl-3-methoxy-phenyl)-2-methyl-propionic acid methyl ester | HCID 20770826 | — |
| Reactant | Methyl 2-(2-oxo-1,2,3,4-tetrahydroquinolin-1-yl)acetate | HCID 21349898 | — |
| Product | (6-Chlorosulfonyl-2-oxo-3,4-dihydro-2H-quinolin-1-yl) acetic acid methyl ester | HCID 20765980 | 28% |
Reaction Steps
Compound 49B was prepared analogously to compound 21B using the product prepared from compound 49A. Yield was 28%. MS m/z 318 (M+1). Step 3. Preparation of (6-Mercapto-2-oxo-3,4-dihydro-2H-quinolin-1-yl}-acetic acid methyl ester (Compound 49C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06875780B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-f9120a41c43946da9e72750acd2106d8 |
| Source note | uspto-grants-2005_04 |