HuagongsheHuagongshe Chemistry Print Report · For research reference only
(6-Chlorosulfonyl-2-oxo-3,4-dihydro-2H-quinolin-1-yl) acetic acid methyl ester → (6-Mercapto-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (6-Chlorosulfonyl-2-oxo-3,4-dihydro-2H-quinolin-1-yl) acetic acid methyl ester | HCID 20765980 | — |
| Reactant | 2-Oxo-6-[4-(4-trifluoromethyl-benzyloxy)-benzylsulfanyl]-3,4-dihydro-2H-quinolin-1-yl-acetic acid methyl ester | HCID 20770801 | — |
| Reactant | 2-(4-Mercapto-3-methoxy-phenyl)-2-methyl propionic acid methyl ester | HCID 20770808 | — |
| Product | (6-Mercapto-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid methyl ester | HCID 20770803 | — |
Reaction Steps
Compound 49C was prepared analogously to compound 21C using the product prepared from compound 49B. Yield was quantitative. MS m/z 252 (M+1). Step 4. Preparation of {2-Oxo-6-[4-(4-trifluoromethyl-benzyloxy)-benzylsulfanyl]-3,4-dihydro-2H-quinolin-1-yl-acetic acid methyl ester (Compound 49D).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06875780B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-26f8450dbd58446eb05ea031843aa566 |
| Source note | uspto-grants-2005_04 |