(6-Hydroxy-5-methyl-benzo[b]thiophen-3-yl)-acetic acid methyl ester → {5-Methyl-6-[2-(4-trifluoromethyl-benzyloxy)-benzyloxy]-benzo[b]-thiophen-3-yl}-acetic acid

Participants

Reaction Steps

The title compound was prepared using compound 78C from the preceding step and compound 7A in a manner analogous to compound 77B. Thus, recrystallization from methanol afforded 0.42 g (43% yield) of the title compound as a cream-colored powder, mp 108-109° C. Calc for C27H23F3O4S: C, 64.79; H, 4.63; found: C, 64.64; H, 4.46. Step 5. Preparation of {5-Methyl-6-[2-(4-trifluoromethyl-benzyloxy)-benzyloxy]-benzo[b]thiophen-3-yl}-acetic acid (Compound 78)

Provenance & Evidence